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In syngeneic mouse models, using the chemically optimized RNAi trigger drug DCR-BCAT, targeting the CTNNB1 gene encoding -catenin, it was found that DCR-BCAT could significantly increase T cell infiltration and enhance tumor sensitivity to ICIs (176)

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Safety Profile: What Clinical Trials Actually Documented Across six clinical trials involving approximately 900 participants, AOD-9604 produced no treatment-related serious adverse events, no immunogenic response, no IGF-1 elevation, and no adverse cardiovascular or metabolic signals